Noyes criteria endometrial dating
Attention to qualitative changes in 8 morphological factors is most useful in dating the endometrial biopsy.
These critera were used in 300 sterility biopsies taken from normally menstruating women over a 3-year period.Absence of organic endometrial disease and availability of accurate menstrual history were the only selection criteria. 42 of the 300 patients (14%) menstruated on the day predicted, 36 (12%) menstruated later, and 222 (74%) menstruated earlier.To determine whether biopsy caused early menstruation, the secretory phases of the 25 patients who had recorded temperatures in at least 2 cycles in addition to that in which the biopsy was taken were examined.The secretory phase was definitely shorter in the biopsied than control cycle, suggesting that biopsy does accelerate the onset of flow.During the 2nd week , stromal changes (including edema), predecidual reaction, stromal mitosis, and leukocytic infiltration are the key criteria.
Tissue from the fundus of the uterus gives the most reliable information.